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Staging and Grading of Prostate Cancer  by: Fritz Frei Staging and Grading Once the diagnosis of prostate cancer has been made the disease has to be staged and graded. The stage refers to the extent and spread of the disease while the grade refers to the nature (aggressiveness) of the particular tumor. Staging will determine the extent of disease and provide important prognostic information that will influence the management decisions. Staging investigations - PSA - X-rays of lumbar spine and pelvis - Chest X-ray - Radionuclitide bone scan - MTI scan of pelvis TNM Staging system T stage (extent of primary lesion) - T1 - tumor confined to prostate, not palpable or visible on TRUS - T2 - tumor palpable or visible on TRUS but confined to prostate - T3 - spread beyond the prostatic capsule - T3a - extracapsular spread only - T3b - involvement of the seminal vesicles - T4 - invasion into rectal wall, bladder neck or pelvic wall N (Nodal) status - N0 - regional nodes not involved - N1 - regional nodes involved by tumor M (Distant Metastases) - M0 - no distant metastases - M1 - distant metastases present Grading Grading refers to what the cancer looks like under a microscope. The most commonly used system is the Gleason grade and score. The glandular pattern is compared to that of a normal prostate and scored out of 5, where 1 resembles a pattern very close to normal and 5 resembles severely distorted glandular architecture. The two predominant glandular patterns within the cancer are graded out of 5 and the combined score calculated out of 10. The higher the Gleason score, the more aggressive is the tumor and the worse is the prognosis. Patients with cancers confined to the prostate (T1 and T2) and no involvement of the lymph nodes or other organs (N0 and M0) are potentially curable by surgery or radiotherapy. Patients with disease beyond the prostate are not curable. With our next information – we will inform you about the “Risk factors for enlarged prostate” – so you should have a look on this site in the next 2 weeks! If you have any question sends us your e-mail. Health-Service-Online Fritz Frei Admin http://www.cancer-info.info About The Author Fritz Frei make it easy to check out the important details about the diagnoses and test's of the prostate cancer. To receive more information's about all cancer -questions - Links and last research NEW's - visit the http://www.cancer-info.info. This article was posted on March 20, 2006 Read More Articles from the "Health" Category: The Natural Way to Heal Cancer by Dr Laurence Magne Hemorrhoids Treatment Using Bioflavonoids by Rudy Silva Is Essential Hypertension A Danger to Your Health? by Tom Nuckels Food for a Healthy Immune System and for Overall Good Health by Patsy Hamilton IBD and Crohn's Disease - What's The Link? by Sarah Jenkins The Truth About Hair Loss by Dr. Rita Louise Useless Exercises That People Still Continue To Do by Adam Kessler Wondering Why To Use a Treadmill? by Roland Dunley A Great Proven Ab Workout by Rob DeMaio Aromatherapy and Essential Oils at a Glance by Sheryl Joaquin << Back to "Health" Index

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